Effect of mevalonate analogues upon cholesterol biosynthesis
نویسنده
چکیده
Three analogues of mevalonic acid have been found to inhibit cholesterol biosynthesis in liver homogenates in the following order of efficacy: 3-methyl-3-hydroxy pentanoic acid > A*3methyl pentenoic acid > As-3-methyl pentenoic acid. The hydroxy acid produces half the maximum inhibition at a concentration of 5 pmoles/ml of homogenate. This corresponds to a ratio of 100 pmoles of inhibitor to 1 amole of substrate.
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تاریخ انتشار 2002